Kebreten F. Manaye

Dr. Manaye earned her undergraduate degree in Haile Sellassie University of Addis Ababa, Ethiopia in 1974, and her M.D. degree from the University of Aristotle, School of Medicine at Thessalonica, Greece in 1984. She joined the Department of Psychiatry at University of Southwestern Medical Center at Dallas, Texas, as a postdoctoral fellow in 1986 and became Assistant Professor in 1990. She moved to the Howard University School of Medicine in 1999 as an Assistant Professor in the Departments of Physiology and Biophysics. Dr. Manaye became tenured Associate Professor in 2005. Furthermore, she has held an adjunct appointment in the Department of Psychiatry at Howard University School of Medicine.

The mission of Dr. Manaye’s Laboratory of Brain Aging and Neurodegeneration is to understand the basic mechanisms that underlie changes in neurons and glial cells under conditions of normal brain aging and degeneration. Her interests include Alzheimer’s disease and depression in humans, and their associated animal models in rodents and non-human primates.

Dr. Manaye is well-published and well-funded by NIH and private research foundations. She is an active member of several professional organizations including AAAS, Society for Neuroscience, and Women Graduate in Science, International Brain Research Organization, and International Stereological Society. She also serves on Annual Brain Awareness as organizer. Dr Manaye has been invited to serve as board of director for International Behavioral Research Press.

Selected Publications

-Rasmussen B.A, O’Neil J.N., Manaye K.F., Perry D.C., Tizabi Y., Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology (Berl). 2007 Jan;190(1):43-9. Epub 2006 Oct 18.

-Long KD, Mastropaolo J, Rosse RB, Manaye KF, Deutsch SI. Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain.Brain Res Bull. 2006 May 31;69(6):626-30. Epub 2006 Mar 30.

-Tizabi, Y., Manaye, K. F., Taylor, R. E.: Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. Neuotoxicity Research pp 319-332 Vol 7 (4)2005.

-Manaye, K.F., Lei, D.L., Dávila-García, M.I., Tizabi, Y., Mouton, and P.R., Kelly, P.H. Selective Cell Loss in the Hypothalamus of Patients suffering from Depression and Bipolar Disorders. J. Neuropathol Exp Neurol. 2005 Mar; 64 (3): 224-9.

-John K. Young; Minfei Wu; Kebreten F. Manaye; Prahba KC; Joanne Allard; Serdia O. Mack and Musa A. Haxhiu. Orexin stimulates breathing via medullary and spinal pathways. J Appl Physiol. 2005 Apr;98(4):1387-95. Epub 2004 Nov 19.

-Marcario, JK, Manaye, KF, Santa Cruz, KS, Mouton, PR, Berman NEJ, Cheney, PD. Severe Subcortical Degeneration in Macaques Infected With Neurovirulent Simian Immunodeficiency Virus. J. Neurovirology, 2004 Dec; 10(6):387-99

-Tizabi, Y., Manaye, K. F., Smoot, D. T., Taylor, R. E. : Nicotine inhibits ethanol-nducedtoxicity in cultured cortical cells. Neurotoxicity Research 2004;6(4):3 311-6.

-Allard, J., Tizabi, Y., Shaffery, J. P., Trouth, C. O., Manaye, K. F. Stereological analysis of hypocretin/orexin neurons in an animal model of depression. Neuropeptides 38 (2004) 311-315

-Tizabi Y, Al-Namaeh M, Manaye KF, Taylor RE. Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells. Neurotox Res. 2003;5(5):315-21.

-Lei DL, Long JM, Hengemihle J, O'Neill J, Manaye KF, Ingram DK, Mouton PR. Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice. Neuroscience. 2003;121(3):659-66.

-Young KA, Manaye KF, Liang C, Hicks PB, German DC. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biol Psychiatry. 2000 Jun 1;47(11):944-53.

-Manaye KF, Zweig R, Wu D, Hersh LB, De Lacalle S, Saper CB, German DC. Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain. Neuroscience. 1999 Mar;89(3):759-70.

-Manaye KF, McIntire DD, Mann DM, German DC. Locus coeruleus cell loss in the aging human brain: a non-random process. J Comp Neurol. 1995 Jul 17; 358(1):79-87.

Active Grant

-NIH/NIMH (PI Project 3) 9/1/04 - 8/31/07
Title: "Depression, Alzheimer’s Disease and Synaptic Connectivity in a Transgenic Mouse Model"

The aims of this project are to elucidate the synaptic connectivity in a transgenic mouse model of Alzheimer’s pathology

-NIH/NINDS -2U54NS039407-06A1 (Project Leader 3) 9/01/05-8/31/2010
Title: "Central Autonomic Control, Aging an Oxidative Stress"
NIH Specialized Neuroscience Research Program

The major goals of this project are to understand the interaction of oxidative stress in inflammatory brain changes during aging and after in-vivo expression of AD-type proteins in double transgenic APP/PS1 model.

-James S. McDonnell Foundation Award Number 28D-1079063 (PI-Howard)2005-2008.
Titled "THE VON ECONOMO NEURONS: A COMPARATIVE AND DEVELOPMENT STUDY"

The major goals of this project are to investigate stereological study of the postnatal development of the VENs using the Nissl stained sections in the development series in the Yakovlev Brain collection for FI and extend this study to include the VENS in ACC and the neurons of the Islands of Calleja and the olfactory tubercule.

-NIH/NIGMS (Co-Investigator) 8/1/06 - 7/31/10
Title: Nicotine, Neurotrophic Factors and Depression

The aims of this project are to elucidate the role of neurotrophic factors in antidepressant or depressogenic effects of nicotine.